Nanoparticles may help prevent tooth decay
#1/8/2016
#Monday
The bacteria that live in dental plaque and contribute to tooth decay often resist traditional antimicrobial treatment, as they can ''hide'' within a sticky bio film matrix, a glue-like polymer scaffold.
Researchers at University of Pennsylvania took a more sophisticated approach. Instead of applying an anti-microbial to the teeth, they took advantage of the pH-sensitivity and enzyme- like properties of iron-containing nano particles to catalyse the activity of hydrogen peroxide, a commonly used natural antiseptic.
The activated hydrogen peroxide produced free radicals that were able to degrade the biofilm matrix and kill the bacteria within, significantly reducing plaque and preventing tooth decay, or cavities, in an animal model.
"Even using a very low concentration of hydrogen peroxide, the process was incredibly effective at disrupting the the biofilm," said Hyunkoo, from the University of Pennsylvania. "Adding nano particles increased the efficiency of bacteria killing more than 5,000-fold," said Koo.
Previous research showed that iron oxide nano particles behave similarly to peroxidase, an enzyme found naturally that catalyses oxidative reactions, often using hydrogen peroxide.
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